|
gptkbp:instanceOf
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antifungal agent
histone deacetylase inhibitor
hydroxamic acid
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|
gptkbp:CASNumber
|
58880-19-6
|
|
gptkbp:chemicalFormula
|
C17H22N2O3
|
|
gptkbp:discoveredBy
|
gptkb:Yoshida_et_al.
|
|
gptkbp:effect
|
induces apoptosis in cancer cells
alters gene expression
induces cell cycle arrest
induces hyperacetylation of histones
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|
https://www.w3.org/2000/01/rdf-schema#label
|
trichostatin A
|
|
gptkbp:IUPACName
|
gptkb:(2E,6E,8E)-7-(4-dimethylaminophenyl)-N-hydroxy-4,6,8-trimethylnona-2,6,8-trienamide
|
|
gptkbp:mechanismOfAction
|
inhibits histone deacetylases (HDACs)
|
|
gptkbp:meltingPoint
|
151–153 °C
|
|
gptkbp:molecularWeight
|
302.37 g/mol
|
|
gptkbp:organism
|
gptkb:Streptomyces_hygroscopicus
|
|
gptkbp:potential_use
|
anticancer agent (preclinical)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEBI:45713
gptkb:CHEMBL413
444732
|
|
gptkbp:solubility
|
soluble in DMSO, ethanol, methanol
|
|
gptkbp:synonym
|
gptkb:TSA
|
|
gptkbp:target
|
gptkb:class_I_and_II_HDACs
|
|
gptkbp:toxicity
|
toxic at high concentrations
|
|
gptkbp:UNII
|
Q6Q474B6F6
|
|
gptkbp:used_in
|
epigenetics research
|
|
gptkbp:usedFor
|
tool compound in chromatin research
|
|
gptkbp:bfsParent
|
gptkb:HDAC2
gptkb:HDAC6
gptkb:HDAC1
|
|
gptkbp:bfsLayer
|
7
|