Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
alkyl hydroperoxide reductase
thioredoxin peroxidase |
| gptkbp:cofactor |
thioredoxin
glutaredoxin |
| gptkbp:discoveredBy |
Dietmar Krause
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:EC_number |
1.11.1.15
|
| gptkbp:enzymeClassification |
oxidoreductase
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
antioxidant enzyme
reduces peroxides |
| gptkbp:hasIsoform |
gptkb:PRDX6
PRDX5 PRDX1 PRDX2 PRDX3 PRDX4 |
| https://www.w3.org/2000/01/rdf-schema#label |
peroxiredoxins
|
| gptkbp:involvedIn |
cancer progression
cell signaling inflammation apoptosis regulation |
| gptkbp:locale |
gptkb:nucleus
mitochondria cytosol peroxisomes extracellular space |
| gptkbp:marking |
gptkb:cancer
neurodegenerative diseases oxidative stress |
| gptkbp:mechanismOfAction |
catalyzes reduction of peroxides via cysteine thiol
|
| gptkbp:PDB |
1QQ2
|
| gptkbp:proteinFamily |
PRDX
|
| gptkbp:regulates |
phosphorylation
oxidative stress overoxidation |
| gptkbp:relatedTo |
catalase
glutathione peroxidase |
| gptkbp:role |
protection against oxidative stress
cellular redox homeostasis |
| gptkbp:structure |
contains conserved cysteine residue
|
| gptkbp:substrate |
hydrogen peroxide
organic hydroperoxides |
| gptkbp:UniProtID |
P0CG48
|
| gptkbp:bfsParent |
gptkb:HDAC6
|
| gptkbp:bfsLayer |
7
|