G protein-coupled receptors (GPCRs)
GPTKB entity
Statements (104)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cell surface receptor |
| gptkbp:activatedBy |
gptkb:G_proteins
|
| gptkbp:alsoKnownAs |
seven-transmembrane receptors
|
| gptkbp:binds |
hormones
neurotransmitters ligands odorants light-sensitive molecules |
| gptkbp:discoveredBy |
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman |
| gptkbp:encodedBy |
GPCR genes
|
| gptkbp:example |
gptkb:receptor_tyrosine_kinase
gptkb:adenosine_receptor gptkb:angiotensin_receptor gptkb:beta-adrenergic_receptor gptkb:glucagon_receptor gptkb:muscarinic_acetylcholine_receptor gptkb:olfactory_receptor gptkb:rhodopsin gptkb:secretin_receptor gptkb:adrenocorticotropic_hormone_receptor gptkb:glutamate_receptor gptkb:melanocortin_receptor cannabinoid receptor neurotrophin receptor dopamine receptor opioid antihistamine bombesin receptor bradykinin receptor calcitonin receptor chemokine receptor endothelin receptor follicle-stimulating hormone receptor free fatty acid receptor frizzled receptor galanin receptor gonadotropin-releasing hormone receptor luteinizing hormone receptor melatonin receptor neuropeptide Y receptor neurotensin receptor parathyroid hormone receptor prostaglandin receptor purinergic receptor somatostatin receptor tachykinin receptor thyrotropin-releasing hormone receptor vasoactive intestinal peptide receptor vasopressin receptor calcitonin gene-related peptide receptor thyroid-stimulating hormone receptor adrenomedullin receptor apelin receptor chemerin receptor ghrelin receptor glucagon-like peptide-1 receptor kisspeptin receptor motilin receptor neurokinin receptor neuromedin U receptor neuropeptide B/W receptor neuropeptide FF receptor neuropeptide S receptor orexin receptor parathyroid hormone 2 receptor prokineticin receptor prolactin-releasing hormone receptor prolactin-releasing peptide receptor relaxin receptor taste receptor pituitary adenylate cyclase-activating polypeptide receptor |
| gptkbp:firstCloned |
1986
|
| gptkbp:firstClonedBy |
gptkb:Robert_Lefkowitz
gptkb:Brian_Kobilka gptkb:Richard_D._Dixon |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
signal transduction
|
| https://www.w3.org/2000/01/rdf-schema#label |
G protein-coupled receptors (GPCRs)
|
| gptkbp:involvedIn |
gptkb:DVD
metabolism cell growth immune response taste smell autonomic nervous system regulation behavioral regulation |
| gptkbp:NobelPrizeYear |
gptkb:2012_Nobel_Prize_in_Chemistry
gptkb:Robert_Lefkowitz gptkb:Brian_Kobilka gptkb:1994_Nobel_Prize_in_Physiology_or_Medicine |
| gptkbp:numberOfGenesInHumanGenome |
over 800
|
| gptkbp:percentageOfDrugsTargeting |
about 34%
|
| gptkbp:structure |
seven transmembrane alpha helices
|
| gptkbp:subspecies |
gptkb:Class_A_(Rhodopsin-like)
gptkb:Class_B_(Secretin_receptor_family) gptkb:Class_C_(Metabotropic_glutamate/pheromone) gptkb:Class_F_(Frizzled/Taste2) |
| gptkbp:target |
pharmaceutical drugs
|
| gptkbp:bfsParent |
gptkb:PI3K_gamma
gptkb:G12/13_protein gptkb:Gs_protein |
| gptkbp:bfsLayer |
6
|