|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:discoveredIn
|
20th century
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:depression
epilepsy
schizophrenia
|
|
gptkbp:encodedBy
|
gptkb:GRIA1
gptkb:GRIA2
gptkb:GRIA3
gptkb:GRIA4
gptkb:GRIK1
gptkb:GRIK2
gptkb:GRIK3
gptkb:GRIK4
gptkb:GRIK5
gptkb:GRIN1
gptkb:GRIN2A
gptkb:GRIN2B
gptkb:GRIN2C
gptkb:GRIN2D
gptkb:GRM3
GRM1
GRM2
GRM4
GRM5
GRM6
GRM7
GRM8
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
mediate excitatory neurotransmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glutamate receptor
|
|
gptkbp:ionotropic_subtype
|
gptkb:AMPA_receptor
gptkb:NMDA_receptor
gptkb:kainate_receptor
|
|
gptkbp:ligand
|
glutamate
|
|
gptkbp:mechanismOfAction
|
gptkb:voltage-gated_potassium_channel
gptkb:G_protein-coupled_receptor
|
|
gptkbp:membraneLocation
|
postsynaptic membrane
presynaptic membrane
|
|
gptkbp:metabotropic_subtype
|
mGluR3
mGluR1
mGluR2
mGluR4
mGluR5
mGluR6
mGluR7
mGluR8
|
|
gptkbp:relatedTo
|
excitotoxicity
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
memory
learning
|
|
gptkbp:subspecies
|
metabotropic glutamate receptor
ionotropic glutamate receptor
|
|
gptkbp:bfsParent
|
gptkb:Metabotropic_glutamate_receptor
gptkb:G_protein-coupled_receptors_(GPCRs)
gptkb:LGIC_family
gptkb:GLUA
gptkb:CHEMBL12313
|
|
gptkbp:bfsLayer
|
7
|