|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:glycogen_synthase_kinase-3_beta
GSK-3B
GSK3beta
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:discoveredBy
|
Dale E. Logie et al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:Entrez_Gene_ID
|
2932
ENSG00000082701
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.26
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase_3_beta
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of Wnt signaling pathway
serine/threonine protein kinase
regulation of glycogen metabolism
|
|
gptkbp:gene
|
gptkb:GSK3B
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Gsk3b
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:CHIR99021
gptkb:lithium_chloride
|
|
gptkbp:locatedOnChromosome
|
3q13.33
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Gsk3b (Mus musculus)
gsk3b (Danio rerio)
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
gptkb:Wnt_signaling_pathway
cell cycle regulation
insulin signaling pathway
|
|
gptkbp:PDB
|
gptkb:1Q4L
4AFJ
|
|
gptkbp:phosphorylates
|
Ser9
Tyr216
|
|
gptkbp:regulates
|
activated by phosphorylation at Tyr216
inhibited by phosphorylation at Ser9
inhibited by insulin signaling
|
|
gptkbp:substrate
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
|
|
gptkbp:UniProtID
|
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:GSK3B
|
|
gptkbp:bfsLayer
|
6
|