Glycogen synthase kinase 3 beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:GSK3B gptkb:glycogen_synthase_kinase-3_beta GSK-3B
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:cancer gptkb:diabetes_mellitus bipolar disorder
gptkbp:discoveredBy	1990
gptkbp:enzymeCommissionNumber	EC 2.7.11.26
gptkbp:expressedIn	gptkb:skeletal_muscle brain liver pancreas
gptkbp:function	serine/threonine protein kinase phosphorylation of glycogen synthase
gptkbp:gene	gptkb:GSK3B
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	4617
gptkbp:inhibitedBy	gptkb:SB-216763 gptkb:CHIR99021 lithium
gptkbp:involves	gptkb:Wnt_signaling_pathway insulin signaling pathway cellular apoptosis
gptkbp:length	420
gptkbp:locatedOnChromosome	3q13.33
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	46 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	Mus musculus Gsk3b Rattus norvegicus Gsk3b
gptkbp:PDB	gptkb:1Q4L gptkb:6Y9S 4NM3
gptkbp:phosphorylates	Ser9 Tyr216
gptkbp:proteinFamily	serine/threonine protein kinase family glycogen synthase kinase family
gptkbp:RefSeq	NM_002093
gptkbp:regulates	activated by phosphorylation at Tyr216 inhibited by phosphorylation at Ser9
gptkbp:substrate	gptkb:glycogen_synthase gptkb:tau_protein gptkb:beta-catenin
gptkbp:UniProtID	gptkb:P49841
gptkbp:bfsParent	gptkb:GSK-3β gptkb:GSK3β gptkb:GSK3B
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Glycogen synthase kinase 3 beta