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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alsoKnownAs
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gptkb:FAK
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Hunter
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
PTK2 gene
|
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gptkbp:Entrez_Gene_ID
|
5747
|
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gptkbp:foundIn
|
focal adhesions
|
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gptkbp:function
|
signal transduction
cell migration
regulation of cell proliferation
regulation of cell survival
cell adhesion
|
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gptkbp:GO
|
gptkb:GO:0004713
gptkb:GO:0005925
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Focal adhesion kinase
|
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gptkbp:inhibitedBy
|
gptkb:defactinib
VS-4718
PF-573228
TAE226
|
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gptkbp:interactsWith
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gptkb:Src
gptkb:PI3K
gptkb:integrins
gptkb:Grb2
gptkb:vinculin
gptkb:GIT1
gptkb:Shc
p130Cas
FAK-binding protein (FIP200)
|
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gptkbp:involvedIn
|
embryonic development
wound healing
angiogenesis
cancer progression
|
|
gptkbp:locatedOnChromosome
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gptkb:8q24.3
|
|
gptkbp:OMIM
|
600758
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
2J0J
|
|
gptkbp:phosphorylates
|
gptkb:Src_family_kinases
gptkb:paxillin
gptkb:talin
Tyr397
Tyr576
Tyr577
Tyr861
Tyr925
|
|
gptkbp:structure
|
contains kinase domain
contains FERM domain
contains FAT domain
|
|
gptkbp:UniProtID
|
Q05397
|
|
gptkbp:bfsParent
|
gptkb:PTK2
|
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gptkbp:bfsLayer
|
6
|