|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:FAK
gptkb:Protein_Tyrosine_Kinase_2
|
|
gptkbp:associatedWith
|
mechanotransduction
focal adhesion turnover
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
focal adhesion
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Hunter
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
gptkb:FAT_domain
kinase domain
FERM domain
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:encodedBy
|
PTK2 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:PTK2
|
|
gptkbp:function
|
signal transduction
cell proliferation regulation
cell survival regulation
cell adhesion regulation
cell migration regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Focal Adhesion Kinase
|
|
gptkbp:inhibitedBy
|
gptkb:defactinib
PF-573228
TAE226
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:integrins
gptkb:Src_family_kinases
gptkb:Grb2
gptkb:paxillin
gptkb:talin
gptkb:Shc
|
|
gptkbp:involvedIn
|
angiogenesis
cancer progression
metastasis
|
|
gptkbp:locatedOnChromosome
|
chromosome 8q24.3 (human)
|
|
gptkbp:molecularWeight
|
~125 kDa
|
|
gptkbp:OMIM
|
600758
|
|
gptkbp:phosphorylates
|
Y397
Y576
Y577
Y861
Y925
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
monomer
|
|
gptkbp:UniProtID
|
Q05397
|
|
gptkbp:bfsParent
|
gptkb:FAK
gptkb:Protein_Tyrosine_Kinase_2
|
|
gptkbp:bfsLayer
|
7
|