Protein Tyrosine Kinase 2

URI: https://gptkb.org/entity/Protein_Tyrosine_Kinase_2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:PTK2 gptkb:Focal_Adhesion_Kinase
gptkbp:associatedWith	gptkb:cancer metastasis
gptkbp:biologicalProcess	cell proliferation cell survival cell motility protein tyrosine kinase activity integrin-mediated signaling pathway
gptkbp:cellularComponent	gptkb:cytoplasm focal adhesion
gptkbp:discoveredBy	gptkb:Tony_Hunter
gptkbp:discoveredIn	1992
gptkbp:encodedBy	PTK2 gene
gptkbp:function	signal transduction cell migration cell adhesion regulation of cell spreading
gptkbp:gene	gptkb:PTK2
https://www.w3.org/2000/01/rdf-schema#label	Protein Tyrosine Kinase 2
gptkbp:inhibitedBy	gptkb:defactinib PF-562271 TAE226
gptkbp:interactsWith	gptkb:integrins gptkb:Src_family_kinases gptkb:paxillin gptkb:talin
gptkbp:length	1052 amino acids
gptkbp:locatedOnChromosome	gptkb:8q24.3
gptkbp:molecularWeight	119 kDa
gptkbp:OMIM	600758
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Danio_rerio gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	gptkb:2AL6 2J0J 1MP8
gptkbp:phosphorylates	Y397 Y576 Y577 Y861 Y925
gptkbp:structure	contains kinase domain contains FERM domain contains FAT domain
gptkbp:UniProtID	Q05397
gptkbp:bfsParent	gptkb:PTK2
gptkbp:bfsLayer	6