|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:APO-1
gptkb:CD95
gptkb:TNFRSF6
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
liver failure
hepatitis
|
|
gptkbp:component
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:Fas_receptor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000026103
355
|
|
gptkbp:expressedIn
|
various tissues
lymphocytes
|
|
gptkbp:function
|
receptor activity
apoptosis induction
regulation of programmed cell death
|
|
gptkbp:GOProcess
|
apoptotic process
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fas gene
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:Fas_ligand
gptkb:caspase-8
|
|
gptkbp:length
|
335 amino acids
|
|
gptkbp:locatedOnChromosome
|
10q23
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
nonsense
missense
frameshift
|
|
gptkbp:OMIM
|
134637
|
|
gptkbp:orthologInMouse
|
gptkb:Fas
Faslpr
|
|
gptkbp:pathway
|
extrinsic apoptotic signaling pathway
|
|
gptkbp:PDB
|
gptkb:3THM
|
|
gptkbp:product
|
gptkb:Fas_receptor
|
|
gptkbp:proteinFamily
|
extracellular domain
transmembrane domain
death domain
|
|
gptkbp:regulates
|
regulated by NF-kB
upregulated by p53
|
|
gptkbp:significance
|
gptkb:cancer
autoimmune diseases
immunodeficiency
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:transcriptionFactorBinding
|
gptkb:STAT1
gptkb:NFAT
|
|
gptkbp:UniProtID
|
gptkb:P25445
|
|
gptkbp:bfsParent
|
gptkb:FAS_gene
|
|
gptkbp:bfsLayer
|
7
|