|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:rhabdomyosarcoma
prostate cancer
hepatocellular carcinoma
muscle development
|
|
gptkbp:cellularComponent
|
integral component of membrane
|
|
gptkbp:domain
|
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:FGFR4_gene
|
|
gptkbp:Entrez_Gene_ID
|
2264
ENSG00000160867
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.10.1
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_4
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:HGNC_ID
|
HGNC:3686
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR4 protein
|
|
gptkbp:interactsWith
|
gptkb:FGF1
gptkb:FGF2
gptkb:FGF6
gptkb:FGF8
gptkb:FGF4
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
wound healing
angiogenesis
|
|
gptkbp:ligand
|
fibroblast growth factor
|
|
gptkbp:locatedOnChromosome
|
5q35.2
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
110 kDa
|
|
gptkbp:OMIM
|
134935
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
4UXQ
|
|
gptkbp:phosphorylates
|
yes
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NP_002006.2
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:signalPeptide
|
yes
|
|
gptkbp:signalTransductionPathway
|
gptkb:MAPK_pathway
gptkb:PLCĪ³_pathway
gptkb:PI3K-Akt_pathway
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P22455
|
|
gptkbp:bfsParent
|
gptkb:FGFR4
|
|
gptkbp:bfsLayer
|
6
|