|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:BCL2L3
MCL1-isoform1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:MCL1_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:family
|
gptkb:Bcl-2_family
|
|
gptkbp:fullName
|
gptkb:Myeloid_cell_leukemia_1
|
|
gptkbp:function
|
anti-apoptotic protein
|
|
gptkbp:gene
|
gptkb:MCL1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mcl-1
|
|
gptkbp:inhibitedBy
|
pro-apoptotic proteins
|
|
gptkbp:interactsWith
|
gptkb:PUMA
gptkb:Bax
gptkb:Bim
gptkb:Noxa
gptkb:Bak
|
|
gptkbp:locatedOnChromosome
|
1q21
|
|
gptkbp:location
|
mitochondrial membrane
|
|
gptkbp:molecularWeight
|
37 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
|
|
gptkbp:PDB
|
2MHS
|
|
gptkbp:phosphorylates
|
stability
|
|
gptkbp:requires
|
embryonic development
hematopoietic cell survival
|
|
gptkbp:role
|
regulation of apoptosis
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:Q07820
|
|
gptkbp:bfsParent
|
gptkb:Bcl-2
gptkb:Bcl-2_protein_family
gptkb:Bcl-2_family_proteins
|
|
gptkbp:bfsLayer
|
7
|