Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
gptkb:FBXW7
gptkb:FBW1 gptkb:Sel-10 |
| gptkbp:binds |
phosphorylated substrates
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:domain |
F-box domain
WD40 repeats |
| gptkbp:encodes |
F-box protein
|
| gptkbp:foundIn |
gptkb:Saccharomyces_cerevisiae
|
| https://www.w3.org/2000/01/rdf-schema#label |
CDC4
|
| gptkbp:involvedIn |
cell cycle regulation
ubiquitin-mediated proteolysis |
| gptkbp:locatedOn |
gptkb:chromosome_IV_(S._cerevisiae)
|
| gptkbp:mutationAssociatedWith |
cell cycle arrest
chromosome instability |
| gptkbp:orthologIn |
gptkb:FBXW7_(human)
|
| gptkbp:partOf |
gptkb:SCF_ubiquitin_ligase_complex
|
| gptkbp:regulates |
gptkb:G1/S_transition
degradation of Sic1 degradation of cyclins |
| gptkbp:requires |
cell viability in yeast
proteasomal degradation of cell cycle regulators |
| gptkbp:bfsParent |
gptkb:InterPro:_IPR001128
gptkb:IPR001806 |
| gptkbp:bfsLayer |
7
|