T-cell acute lymphoblastic leukemia

URI: https://gptkb.org/entity/T-cell_acute_lymphoblastic_leukemia
GPTKB entity
Statements (58)
Predicate Object
gptkbp:instanceOf gptkb:leukemia
gptkb:disease
gptkbp:abbreviation gptkb:T-ALL
gptkbp:affects adolescents
adults
children
T lymphocytes
gptkbp:hasCellMarker gptkb:TdT
gptkb:CD3
gptkb:CD4
gptkb:CD8
gptkb:CD7
gptkb:CD1a
CD2
CD5
gptkbp:hasDiagnosticMethod bone marrow biopsy
cytogenetic analysis
immunophenotyping
flow cytometry
gptkbp:hasGeneticAlteration gptkb:NOTCH1_mutation
PTEN mutation
CDKN2A deletion
TAL1 rearrangement
TLX1 overexpression
gptkbp:hasOrphanetID 99860
gptkbp:hasRelapseRate higher than B-cell ALL
gptkbp:hasTypicalOnset childhood
adolescence
young adulthood
gptkbp:ICD-10_code gptkb:C91.0
gptkbp:incidence less common than B-cell ALL
gptkbp:MedlinePlusID 000573
gptkbp:MeSH_ID D015454
gptkbp:OMIM 613065
gptkbp:prognosis variable
worse than B-cell ALL
gptkbp:riskFactor gptkb:Down_syndrome
gptkb:Fanconi_anemia
gptkb:ataxia-telangiectasia
gptkb:neurofibromatosis_type_1
radiation exposure
genetic predisposition
gptkbp:subclassOf gptkb:leukemia
gptkbp:symptom fever
bleeding
fatigue
hepatosplenomegaly
lymphadenopathy
bone pain
pallor
mediastinal mass
gptkbp:treatment gptkb:radiation_therapy
gptkb:targeted_therapy
chemotherapy
stem cell transplantation
gptkbp:bfsParent gptkb:LMO
gptkbp:bfsLayer 6
https://www.w3.org/2000/01/rdf-schema#label T-cell acute lymphoblastic leukemia