T-cell acute lymphoblastic leukemia
GPTKB entity
Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
leukemia |
| gptkbp:abbreviation |
gptkb:T-ALL
|
| gptkbp:affects |
adolescents
adults children T lymphocytes |
| gptkbp:hasCellMarker |
gptkb:TdT
gptkb:CD3 gptkb:CD4 gptkb:CD8 gptkb:CD7 gptkb:CD1a CD2 CD5 |
| gptkbp:hasDiagnosticMethod |
bone marrow biopsy
cytogenetic analysis immunophenotyping flow cytometry |
| gptkbp:hasGeneticAlteration |
gptkb:NOTCH1_mutation
PTEN mutation CDKN2A deletion TAL1 rearrangement TLX1 overexpression |
| gptkbp:hasOrphanetID |
99860
|
| gptkbp:hasRelapseRate |
higher than B-cell ALL
|
| gptkbp:hasTypicalOnset |
childhood
adolescence young adulthood |
| https://www.w3.org/2000/01/rdf-schema#label |
T-cell acute lymphoblastic leukemia
|
| gptkbp:ICD-10_code |
gptkb:C91.0
|
| gptkbp:incidence |
less common than B-cell ALL
|
| gptkbp:MedlinePlusID |
000573
|
| gptkbp:MeSH_ID |
D015454
|
| gptkbp:OMIM |
613065
|
| gptkbp:prognosis |
variable
worse than B-cell ALL |
| gptkbp:riskFactor |
gptkb:Down_syndrome
gptkb:Fanconi_anemia gptkb:ataxia-telangiectasia gptkb:neurofibromatosis_type_1 radiation exposure genetic predisposition |
| gptkbp:subclassOf |
leukemia
|
| gptkbp:symptom |
fever
bleeding fatigue hepatosplenomegaly lymphadenopathy bone pain pallor mediastinal mass |
| gptkbp:treatment |
radiation therapy
chemotherapy stem cell transplantation targeted therapy |
| gptkbp:bfsParent |
gptkb:T-cell_ALL
gptkb:LMO |
| gptkbp:bfsLayer |
6
|