|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ENX-1
gptkb:Enhancer_of_zeste_2_polycomb_repressive_complex_2_subunit
gptkb:KMT6
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
prostate cancer
|
|
gptkbp:catalyzes
|
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
|
gptkbp:component
|
gptkb:PRC2_complex
gptkb:Polycomb_Repressive_Complex_2
nucleoplasm
|
|
gptkbp:encodedBy
|
gptkb:EZH2_gene
|
|
gptkbp:Entrez_Gene_ID
|
2146
|
|
gptkbp:enzymeCommissionNumber
|
2.1.1.43
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:fullName
|
gptkb:Enhancer_of_zeste_homolog_2
|
|
gptkbp:function
|
histone methyltransferase
histone-lysine N-methyltransferase activity
|
|
gptkbp:gene
|
gptkb:EZH2
|
|
gptkbp:GOProcess
|
regulation of transcription, DNA-templated
chromatin silencing
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EZH2 (human)
|
|
gptkbp:inhibitedBy
|
gptkb:Tazemetostat
gptkb:GSK126
|
|
gptkbp:interactsWith
|
gptkb:EED
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:molecularWeight
|
85 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Weaver_syndrome
myeloid malignancies
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ezh2_(mouse)
gptkb:Ezh2_(rat)
|
|
gptkbp:PDB
|
gptkb:5HYN
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_004447.2
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:target
|
anticancer drugs
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q15910
|
|
gptkbp:bfsParent
|
gptkb:Drosophila_E(z)
|
|
gptkbp:bfsLayer
|
7
|