|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:amendedBy
|
gptkb:histone_H3
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:X-chromosome_inactivation
stem cell pluripotency
|
|
gptkbp:catalyzes
|
trimethylation of H3K27
|
|
gptkbp:component
|
gptkb:EED
gptkb:RBBP7
gptkb:EZH2
gptkb:EZH1
gptkb:PHF19
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
gptkb:RBBP4
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:enemyOf
|
gptkb:Trithorax_group_proteins
|
|
gptkbp:firstDescribed
|
1998
|
|
gptkbp:fullName
|
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:function
|
gene silencing
histone methyltransferase activity
|
|
gptkbp:geneEncodingComponent
|
gptkb:EZH2_gene
EED gene
SUZ12 gene
RBBP4 gene
AEBP2 gene
JARID2 gene
PHF19 gene
RBBP7 gene
|
|
gptkbp:inhibitedBy
|
gptkb:EPZ-6438
gptkb:GSK126
|
|
gptkbp:interactsWith
|
long non-coding RNAs
|
|
gptkbp:involvedIn
|
epigenetic regulation
developmental gene repression
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Weaver_syndrome
various cancers
|
|
gptkbp:orthologIn
|
animals
fungi
mammals
plants
|
|
gptkbp:recruitedFrom
|
transcription factors
DNA methylation
|
|
gptkbp:regulates
|
gptkb:HOX_genes
cell fate determination
|
|
gptkbp:requires
|
embryonic development
maintenance of cell identity
|
|
gptkbp:bfsParent
|
gptkb:ASXL1
gptkb:AEBP2
gptkb:EPZ-6438
gptkb:EZH2_(human)
gptkb:Polycomb_group_(PcG)_pathway
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PRC2 complex
|