Polycomb Repressive Complex 2

URI: https://gptkb.org/entity/Polycomb_Repressive_Complex_2
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:PRC2
gptkbp:associatedWith gptkb:Polycomb_group_proteins
gptkbp:catalyzes trimethylation of histone H3 at lysine 27
gptkbp:component gptkb:EED
gptkb:RBBP7
gptkb:EZH2
gptkb:EPOP
gptkb:PHF19
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
gptkb:RBBP4
gptkbp:discoveredIn gptkb:Drosophila_melanogaster
gptkbp:enemyOf gptkb:Trithorax_group_proteins
gptkbp:form repressive chromatin domains
gptkbp:function histone methyltransferase
gptkbp:GO_term GO:0005634 (nucleus)
GO:0006342 (chromatin silencing)
GO:0016571 (histone methylation)
gptkbp:hasBiologicalActivity histone-lysine N-methyltransferase activity
https://www.w3.org/2000/01/rdf-schema#label Polycomb Repressive Complex 2
gptkbp:inhibitedBy EZH2 inhibitors
gptkbp:involvedIn gptkb:cancer
cell differentiation
development
epigenetic gene silencing
gptkbp:locale gptkb:nucleus
gptkbp:mutationAssociatedWith gptkb:Weaver_syndrome
various cancers
gptkbp:orthologIn gptkb:Drosophila_PRC2
gptkbp:PDB gptkb:6C23
gptkb:5HYN
gptkbp:recruitedFrom DNA methylation
long non-coding RNAs
gptkbp:regulates gptkb:X-chromosome_inactivation
gene expression
pluripotency
oncogenes
cell cycle
chromatin structure
stem cell maintenance
tumor suppressor genes
gptkbp:requires embryonic development
gptkbp:significance target for cancer therapy
biomarker in oncology
gptkbp:subunit EZH1 (alternative to EZH2 in some complexes)
gptkbp:target gptkb:Hox_gene_clusters
gptkbp:bfsParent gptkb:Drosophila_E(z)
gptkb:Polycomb-group_proteins
gptkbp:bfsLayer 7