|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:EZH2_HUMAN
gptkb:ENX1
gptkb:KMT6
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
prostate cancer
|
|
gptkbp:catalyzes
|
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:encodedBy
|
gptkb:EZH2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000106462
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:fullName
|
gptkb:Enhancer_of_zeste_homolog_2
|
|
gptkbp:function
|
histone methyltransferase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3527
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ezh2
|
|
gptkbp:inhibitedBy
|
gptkb:tazemetostat
|
|
gptkbp:interactsWith
|
gptkb:EED
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
|
|
gptkbp:length
|
751 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:molecularWeight
|
85 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Weaver_syndrome
|
|
gptkbp:OMIM
|
601573
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell proliferation
gene silencing
stem cell maintenance
|
|
gptkbp:UniProtID
|
gptkb:Q15910
|
|
gptkbp:bfsParent
|
gptkb:EZH2
|
|
gptkbp:bfsLayer
|
7
|