Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
histone modification
|
| gptkbp:component |
gptkb:Polycomb_Repressive_Complex_1_(PRC1)
gptkb:Polycomb_Repressive_Complex_2_(PRC2) |
| gptkbp:discoveredIn |
gptkb:Drosophila_melanogaster
|
| gptkbp:firstDescribed |
1978
|
| gptkbp:foundIn |
animals
fungi plants |
| gptkbp:function |
epigenetic gene silencing
|
| https://www.w3.org/2000/01/rdf-schema#label |
Polycomb-group (PcG) family
|
| gptkbp:includes |
gptkb:RING1
gptkb:Enhancer_of_zeste_(E(z)) gptkb:Polycomb_(Pc) gptkb:Polyhomeotic_(Ph) gptkb:Posterior_sex_combs_(Psc) gptkb:Suppressor_of_zeste_12_(Su(z)12) BMI1 |
| gptkbp:mechanismOfAction |
histone methylation
histone ubiquitination |
| gptkbp:namedAfter |
gptkb:Polycomb_gene
|
| gptkbp:opposedBy |
gptkb:Trithorax-group_(TrxG)_family
|
| gptkbp:regulates |
chromatin structure
Hox gene expression |
| gptkbp:role |
gptkb:cancer
cell fate determination stem cell maintenance developmental gene regulation |
| gptkbp:bfsParent |
gptkb:EZH2
|
| gptkbp:bfsLayer |
7
|