Receptor tyrosine-protein kinase erbB-3

URI: https://gptkb.org/entity/Receptor_tyrosine-protein_kinase_erbB-3
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:ERBB3
gptkb:HER3
gptkbp:discoveredBy Stuart A. Aaronson
gptkbp:discoveredIn 1989
gptkbp:encodedBy ERBB3 gene
gptkbp:Entrez_Gene_ID 2065
ENSG00000065361
gptkbp:expressedIn gptkb:nervous_system
epithelial tissues
gptkbp:function cell signaling
regulation of cell differentiation
regulation of cell growth
receptor tyrosine kinase activity
https://www.w3.org/2000/01/rdf-schema#label Receptor tyrosine-protein kinase erbB-3
gptkbp:interactsWith gptkb:ERBB2
neuregulins
gptkbp:ligand neuregulin-1
neuregulin-2
neuregulin-3
neuregulin-4
gptkbp:locale gptkb:cell_membrane
gptkbp:locatedOnChromosome chromosome 12q13
gptkbp:memberOf gptkb:ErbB_family
gptkbp:molecularWeight ~148 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
colorectal cancer
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:lion
gptkb:mouse
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
right
gptkbp:pathway MAPK signaling
PI3K/AKT signaling
gptkbp:PDB 1M6B
gptkbp:phosphorylates tyrosine residues
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:proteinFamily protein tyrosine kinase family
EGF receptor family
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:significance implicated in cancer
gptkbp:structure extracellular ligand-binding domain
single transmembrane domain
intracellular tyrosine kinase domain (impaired activity)
gptkbp:UniProtID P21860
gptkbp:bfsParent gptkb:ERBB3
gptkbp:bfsLayer 7