Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:HER3
|
| gptkbp:discoveredIn |
1989
|
| gptkbp:encodedBy |
ERBB3 gene
|
| gptkbp:formsHeterodimerWith |
ErbB-2
ErbB-4 |
| gptkbp:function |
gptkb:receptor_tyrosine_kinase
|
| https://www.w3.org/2000/01/rdf-schema#label |
ErbB-3
|
| gptkbp:interactsWith |
gptkb:PI3K
ErbB-2 |
| gptkbp:kinaseActivity |
impaired
|
| gptkbp:ligand |
neuregulin
|
| gptkbp:locatedOnChromosome |
chromosome 12q13
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:memberOf |
gptkb:ErbB_family
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
colorectal cancer |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:role |
gptkb:cancer
differentiation cell growth |
| gptkbp:structure |
transmembrane domain
extracellular ligand-binding domain intracellular tyrosine kinase domain |
| gptkbp:target |
anticancer drugs
|
| gptkbp:UniProtID |
P21860
|
| gptkbp:bfsParent |
gptkb:ERBB3
|
| gptkbp:bfsLayer |
7
|