|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:HER3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
|
|
gptkbp:discoveredBy
|
Yarden Y et al.
|
|
gptkbp:encodes
|
gptkb:Receptor_tyrosine-protein_kinase_erbB-3
|
|
gptkbp:Entrez_Gene_ID
|
2065
ENSG00000065361
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:formsHeterodimerWith
|
ErbB2
|
|
gptkbp:function
|
signal transduction
receptor tyrosine kinase activity
|
|
gptkbp:GO_term
|
GO:0005524
GO:0005007
GO:0007169
|
|
gptkbp:hasKinaseActivity
|
impaired
|
|
gptkbp:hasMIMNumber
|
190151
|
|
gptkbp:hasRefSeqID
|
NM_001982
|
|
gptkbp:HGNC_ID
|
3430
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Erbb3
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:length
|
1342 amino acids
|
|
gptkbp:ligand
|
neuregulins
|
|
gptkbp:locatedOnChromosome
|
chromosome 12q13.2
|
|
gptkbp:memberOf
|
gptkb:ErbB_family
|
|
gptkbp:molecularWeight
|
148 kDa
|
|
gptkbp:OMIM
|
190151
|
|
gptkbp:orthologInMouse
|
Erbb3 (mouse)
Erbb3 (rat)
|
|
gptkbp:pathway
|
gptkb:EGFR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:PDB
|
4RIY
|
|
gptkbp:phosphorylates
|
ErbB2
|
|
gptkbp:proteinFamily
|
EGF-like domain
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P21860
|
|
gptkbp:bfsParent
|
gptkb:ERBB3
|
|
gptkbp:bfsLayer
|
7
|