|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:affects
|
pharmacogenomics
pharmacokinetics
drug response
|
|
gptkbp:catalyzes
|
drug metabolism
xenobiotic metabolism
hydroxylation reactions
|
|
gptkbp:discoveredBy
|
gptkb:Ulf_von_Euler
|
|
gptkbp:EC_number
|
1.14.13.13
|
|
gptkbp:encodedBy
|
gptkb:CYP2C19_gene
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:gene
|
gptkb:CYP2C19
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2C19*17
gptkb:CYP2C19*2
gptkb:CYP2C19*3
|
|
gptkbp:HGNC_ID
|
2621
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytochrome P450 2C19
|
|
gptkbp:inducedBy
|
gptkb:rifampin
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:fluvoxamine
gptkb:fluconazole
gptkb:omeprazole
gptkb:ticlopidine
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q23.33
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:metabolism
|
gptkb:phenytoin
gptkb:voriconazole
gptkb:omeprazole
gptkb:clopidogrel
gptkb:lansoprazole
gptkb:diazepam
gptkb:mephenytoin
gptkb:proguanil
|
|
gptkbp:OMIM
|
124020
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2c11
gptkb:Cyp2c29
|
|
gptkbp:relatedTo
|
personalized medicine
adverse drug reactions
pharmacogenetic testing
poor metabolizer phenotype
ultrarapid metabolizer phenotype
extensive metabolizer phenotype
intermediate metabolizer phenotype
|
|
gptkbp:UniProtID
|
gptkb:P33261
|
|
gptkbp:bfsParent
|
gptkb:ENSG00000101972
|
|
gptkbp:bfsLayer
|
7
|