Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
antiviral drug |
| gptkbp:ATCCode |
P01BB01
|
| gptkbp:CASNumber |
500-92-5
|
| gptkbp:chemicalFormula |
C11H16ClN5
|
| gptkbp:combines |
gptkb:atovaquone
chloroquine |
| gptkbp:discoveredBy |
gptkb:Imperial_Chemical_Industries
|
| gptkbp:discoveredIn |
1944
|
| gptkbp:eliminationHalfLife |
12-21 hours
|
| gptkbp:excretion |
urine
|
| https://www.w3.org/2000/01/rdf-schema#label |
proguanil
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
inhibits dihydrofolate reductase
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
253.73 g/mol
|
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:PubChem_CID |
4911
|
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
diarrhea abdominal pain mouth ulcers |
| gptkbp:synonym |
chloroguanide
paludrine |
| gptkbp:UNII |
6R8Q6P833E
|
| gptkbp:usedFor |
malaria treatment
malaria prevention |
| gptkbp:WHOModelListOfEssentialMedicines |
yes
|
| gptkbp:bfsParent |
gptkb:CYP2C19
gptkb:atovaquone-proguanil gptkb:atovaquone |
| gptkbp:bfsLayer |
6
|