|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alias
|
Cell division cycle 25A
M-phase inducer phosphatase 1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:encodedBy
|
CDC25A gene
|
|
gptkbp:Entrez_Gene_ID
|
993
ENSG00000164045
|
|
gptkbp:enzymeClassification
|
phosphatase
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
cell cycle regulation
dephosphorylation of cyclin-dependent kinases
|
|
gptkbp:gene
|
CDC25A
|
|
gptkbp:HGNC_ID
|
1724
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cdc25A
|
|
gptkbp:inhibitedBy
|
DNA damage
checkpoint kinases
|
|
gptkbp:locatedOnChromosome
|
3p21.3
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~56 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
116949
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
|
|
gptkbp:PDB
|
1C25
|
|
gptkbp:phosphorylates
|
gptkb:CHK2
CHK1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
proteolysis
|
|
gptkbp:RefSeq
|
NM_001789
|
|
gptkbp:regulates
|
gptkb:APC/C
gptkb:E2F_transcription_factors
gptkb:p53
gptkb:G1/S_transition
G2/M transition
SCF complex
|
|
gptkbp:relatedTo
|
Cdc25C
Cdc25B
|
|
gptkbp:substrate
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
P30304
|
|
gptkbp:bfsParent
|
gptkb:PIM_1
|
|
gptkbp:bfsLayer
|
7
|