|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PIM1_kinase
gptkb:PIM1_proto-oncogene,_serine/threonine_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
prostate cancer
hematological malignancies
|
|
gptkbp:discoveredBy
|
gptkb:Anton_Berns
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:PIM1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5292
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.2
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:fullName
|
gptkb:Proto-oncogene_serine/threonine-protein_kinase_Pim-1
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
gptkbp:HGNC_ID
|
8986
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIM 1
|
|
gptkbp:inhibitedBy
|
gptkb:AZD1208
gptkb:SGI-1776
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:OMIM
|
176914
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
leukemia
|
|
gptkbp:PDB
|
2C3I
|
|
gptkbp:phosphorylates
|
gptkb:BAD
gptkb:p21
gptkb:p27
gptkb:Cdc25A
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:PIM_kinase_family
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
transcription factors
cell cycle proteins
|
|
gptkbp:relatedTo
|
gptkb:PIM_2
gptkb:PIM_3
|
|
gptkbp:role
|
cell cycle progression
tumorigenesis
apoptosis inhibition
|
|
gptkbp:structure
|
monomer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P11309
|
|
gptkbp:bfsParent
|
gptkb:Pondok_Indah_Mall
|
|
gptkbp:bfsLayer
|
6
|