juvenile myelomonocytic leukemia

URI: https://gptkb.org/entity/juvenile_myelomonocytic_leukemia
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:disease
leukemia
gptkbp:abbreviation JMML
gptkbp:affects children
infants
gptkbp:causedBy gptkb:KRAS_mutation
genetic disorder
NRAS mutation
CBL mutation
NF1 mutation
PTPN11 mutation
RAS pathway mutation
gptkbp:firstDescribed 1975
gptkbp:hasOrphanetID ORPHA:99860
https://www.w3.org/2000/01/rdf-schema#label juvenile myelomonocytic leukemia
gptkbp:ICD-10_code C93.5
gptkbp:incidence rare
gptkbp:medianAge 2 years
gptkbp:MeSH_ID gptkb:D015464
gptkbp:OMIM 607785
gptkbp:originatedIn myelomonocytic cells
gptkbp:prognosis variable
gptkbp:riskFactor gptkb:Noonan_syndrome
gptkb:neurofibromatosis_type_1
gptkbp:subspecies gptkb:myelodysplastic/myeloproliferative_neoplasm
gptkbp:symptom fever
bleeding
hepatosplenomegaly
lymphadenopathy
skin rash
pallor
gptkbp:treatment chemotherapy
hematopoietic stem cell transplantation
gptkbp:bfsParent gptkb:CBL_gene
gptkb:NF1
gptkb:NF1_gene
gptkb:PTPN11
gptkb:PTPN11_gene
gptkb:juvenile_xanthogranuloma
gptkb:c-Cbl
gptkbp:bfsLayer 7