|
gptkbp:instanceOf
|
gptkb:gene
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
no
|
|
gptkbp:associatedWith
|
cancer risk
drug-drug interactions
caffeine sensitivity
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_1A2
|
|
gptkbp:Entrez_Gene_ID
|
1544
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:expressedIn
|
liver
|
|
gptkbp:fullName
|
gptkb:cytochrome_P450_family_1_subfamily_A_member_2
|
|
gptkbp:function
|
drug metabolism
xenobiotic metabolism
caffeine metabolism
metabolism of polycyclic aromatic hydrocarbons
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP1A2*1C
gptkb:CYP1A2*1F
gptkb:CYP1A2*1K
|
|
gptkbp:HGNC_ID
|
2595
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP1A2
|
|
gptkbp:inducedBy
|
smoking
cruciferous vegetables
|
|
gptkbp:inhibitedBy
|
gptkb:fluvoxamine
ciprofloxacin
oral contraceptives
|
|
gptkbp:length
|
515 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
gptkb:15q24.1
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:OMIM
|
124060
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp1a2
|
|
gptkbp:PDB
|
2HI4
2J0D
2J0M
|
|
gptkbp:regulates
|
gptkb:aryl_hydrocarbon_receptor_(AhR)
gptkb:nuclear_factor-1
|
|
gptkbp:substrate
|
gptkb:theophylline
gptkb:R-warfarin
gptkb:tacrine
gptkb:clozapine
caffeine
acetaminophen
phenacetin
|
|
gptkbp:UniProtID
|
gptkb:P05177
|
|
gptkbp:bfsParent
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|