|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
altered drug response
drug-induced toxicity
|
|
gptkbp:chromosomeArm
|
10q24
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_2C8
|
|
gptkbp:Entrez_Gene_ID
|
1558
|
|
gptkbp:enzyme
|
monooxygenase
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.13.93
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:small_intestine
liver
|
|
gptkbp:foundIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2C8*2
gptkb:CYP2C8*3
gptkb:CYP2C8*4
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:2591
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2C8
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:fluconazole
gptkb:clopidogrel
gptkb:gemfibrozil
gptkb:montelukast
trimethoprim
|
|
gptkbp:involvedIn
|
drug metabolism
xenobiotic metabolism
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:OMIM
|
601134
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2c11
gptkb:Cyp2c29
|
|
gptkbp:referenceGenome
|
NM_000770
|
|
gptkbp:referenceProteinSequence
|
NP_000761
|
|
gptkbp:substrate
|
gptkb:ibuprofen
gptkb:cerivastatin
gptkb:repaglinide
gptkb:zafirlukast
gptkb:pioglitazone
gptkb:rosiglitazone
gptkb:amodiaquine
gptkb:loperamide
gptkb:rosuvastatin
gptkb:montelukast
paclitaxel
|
|
gptkbp:UniProtID
|
P10632
|
|
gptkbp:bfsParent
|
gptkb:CYP2_family
|
|
gptkbp:bfsLayer
|
5
|