loperamide

GPTKB entity

Statements (58)
Predicate Object
gptkbp:instanceOf gptkb:drug
opioid receptor agonist
gptkbp:abusePotential high (at very high doses)
low (at recommended doses)
gptkbp:ATCCode A07DA03
gptkbp:brand gptkb:Imodium
gptkbp:CASNumber 53179-11-6
gptkbp:chemicalFormula C29H33ClN2O2
piperidine derivative
gptkbp:contraindication gptkb:pseudomembranous_colitis
children under 2 years
bacterial enterocolitis
bloody diarrhea
gptkbp:discoveredBy gptkb:Paul_Janssen
gptkbp:discoveredIn 1969
gptkbp:doesNotCross blood-brain barrier (in normal doses)
gptkbp:drugClass antidiarrheal
peripherally acting opioid
gptkbp:eliminationHalfLife 9-14 hours
gptkbp:excretion feces
urine (minor)
gptkbp:FDAApproved 1976
https://www.w3.org/2000/01/rdf-schema#label loperamide
gptkbp:interactsWith gptkb:desmopressin
gptkb:ritonavir
gptkb:gemfibrozil
gptkb:erythromycin
gptkb:ketoconazole
gptkb:verapamil
quinidine
gptkbp:lactationSafety caution advised
gptkbp:legalStatus OTC (over-the-counter) in many countries
Rx-only in some countries
gptkbp:marketedAs gptkb:Janssen_Pharmaceutica
gptkbp:mechanismOfAction mu-opioid receptor agonist in the gut
gptkbp:MedlinePlusID a682280
gptkbp:metabolism gptkb:CYP2C8
gptkb:CYP3A4
liver
gptkbp:molecularWeight 477.04 g/mol
gptkbp:overdoseSymptoms gptkb:arrhythmia
QT prolongation
CNS depression (at very high doses)
gptkbp:patent 1972
gptkbp:pregnancyCategory gptkb:B3
B (US)
gptkbp:PubChem_CID 3955
DB00836
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
abdominal pain
constipation
drowsiness
gptkbp:UNII 6X9OC3H4II
gptkbp:usedFor diarrhea
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:Imodium
gptkbp:bfsLayer 5