|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:AXIN
PPP1R49
huAxin
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:medulloblastoma
colorectal cancer
hepatocellular carcinoma
|
|
gptkbp:biologicalProcess
|
apoptosis
cell proliferation
cell signaling
scaffold protein
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodes
|
Axin-1 protein
|
|
gptkbp:Entrez_Gene_ID
|
8312
ENSG00000103126
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
axin 1
|
|
gptkbp:function
|
negative regulator of Wnt signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:903
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AXIN1
|
|
gptkbp:interactsWith
|
gptkb:GSK3B
gptkb:SMAD3
gptkb:CTNNB1
gptkb:APC
gptkb:TP53
gptkb:DVL1
gptkb:beta-catenin
|
|
gptkbp:length
|
862
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_16
|
|
gptkbp:molecularWeight
|
96 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenesis
|
|
gptkbp:OMIM
|
603816
|
|
gptkbp:orthologInMouse
|
Axin1
|
|
gptkbp:phosphorylates
|
yes
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:Wnt_signaling_pathway
beta-catenin degradation
|
|
gptkbp:symbol
|
gptkb:AXIN1
|
|
gptkbp:UniProtID
|
O15169
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1
|
|
gptkbp:bfsLayer
|
5
|