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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:APC/C
|
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gptkbp:associatedWith
|
gptkb:cancer
|
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gptkbp:catalyzes
|
ubiquitination of target proteins
|
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gptkbp:coactivator
|
gptkb:CDC20
gptkb:CDH1
|
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gptkbp:database
|
Reactome:R-HSA-174143
UniProt:Q9UJX2
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gptkbp:discoveredIn
|
1995
|
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gptkbp:EC_number
|
2.3.2.27
|
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gptkbp:fullName
|
gptkb:Anaphase-Promoting_Complex
|
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gptkbp:function
|
gptkb:ubiquitin_ligase
regulation of cell cycle
|
|
gptkbp:GO_term
|
GO:0005680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APC complex
|
|
gptkbp:inhibitedBy
|
gptkb:BubR1
gptkb:Emi1
gptkb:Mad2
|
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gptkbp:involvedIn
|
meiosis
mitosis
|
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gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~1.5 MDa
|
|
gptkbp:regulates
|
phosphorylation
exit from mitosis
metaphase-anaphase transition
binding of co-activators
|
|
gptkbp:relatedTo
|
cell division
chromosome segregation
proteolysis
|
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gptkbp:species
|
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
|
|
gptkbp:subunit
|
gptkb:APC1
gptkb:APC10
gptkb:APC2
gptkb:APC4
gptkb:APC5
gptkb:APC7
gptkb:APC9
gptkb:CDC20
APC11
APC13
APC3 (CDC27)
APC6 (CDC16)
APC8 (CDC23)
CDH1 (FZR1)
APC12
|
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gptkbp:target
|
gptkb:cyclin_B
gptkb:securin
|
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gptkbp:bfsParent
|
gptkb:CTNNB1
|
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gptkbp:bfsLayer
|
5
|