|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TCF4
Transcription factor 4
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:alternativeTranscripts
|
multiple
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
colorectal cancer
|
|
gptkbp:biologicalProcess
|
gptkb:Wnt_signaling_pathway
DNA-binding transcription factor activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
van de Wetering et al.
|
|
gptkbp:encodes
|
Transcription factor 7-like 2 protein
|
|
gptkbp:Entrez_Gene_ID
|
6934
ENSG00000148737
|
|
gptkbp:expressedIn
|
gptkb:islets_of_Langerhans
brain
liver
colon
pancreas
intestine
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:fullName
|
Transcription factor 7-like 2
|
|
gptkbp:function
|
transcription factor in Wnt signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:LEF1
gptkb:TCF7
gptkb:TCF7L1
|
|
gptkbp:HGNC_ID
|
11641
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TCF7L2
|
|
gptkbp:interactsWith
|
gptkb:beta-catenin
|
|
gptkbp:length
|
596 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q25.2-q25.3
10
|
|
gptkbp:memberOf
|
gptkb:TCF/LEF_family
|
|
gptkbp:mutationAssociatedWith
|
increased risk of type 2 diabetes
|
|
gptkbp:OMIM
|
602228
|
|
gptkbp:orthologInMouse
|
Tcf7l2
|
|
gptkbp:pathway
|
glucose metabolism
Wnt/beta-catenin signaling
|
|
gptkbp:product
|
TCF7L2 protein
|
|
gptkbp:regulates
|
Wnt target genes
Wnt response element
proglucagon gene expression
|
|
gptkbp:significance
|
potential therapeutic target
risk marker for type 2 diabetes
|
|
gptkbp:SNP
|
rs12255372
rs7903146
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
Q9NQB0
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1
|
|
gptkbp:bfsLayer
|
5
|