|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BULN2
gptkb:MGC34632
gptkb:abrineurin
gptkb:proBDNF
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:depression
bipolar disorder
schizophrenia
neurodegenerative diseases
psychiatric disorders
|
|
gptkbp:discoveredBy
|
gptkb:Yves-Alain_Barde
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:BDNF_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000176697
627
|
|
gptkbp:expressedIn
|
brain
peripheral tissues
|
|
gptkbp:fullName
|
gptkb:brain-derived_neurotrophic_factor
|
|
gptkbp:function
|
gptkb:synaptic_plasticity
learning and memory
regulation of neuronal survival and growth
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:Val66Met
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:1034
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BDNF gene
|
|
gptkbp:interactsWith
|
gptkb:TrkB_receptor
gptkb:p75NTR_receptor
|
|
gptkbp:length
|
about 70 kb
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:mutationAssociatedWith
|
can affect cognitive function
can cause neurodevelopmental disorders
|
|
gptkbp:numberOfExons
|
11
|
|
gptkbp:OMIM
|
113505
|
|
gptkbp:orthologInMouse
|
Bdnf
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Neurotrophin_signaling_pathway
|
|
gptkbp:proteinFamily
|
gptkb:NGF_domain
neurotrophin family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
epigenetic mechanisms
activity-dependent
hormonal regulation
|
|
gptkbp:symbol
|
gptkb:BDNF
|
|
gptkbp:UniProtID
|
gptkb:P23560
|
|
gptkbp:Val66Met_effect
|
alters activity-dependent secretion of BDNF protein
|
|
gptkbp:bfsParent
|
gptkb:brain-derived_neurotrophic_factor
|
|
gptkbp:bfsLayer
|
6
|