|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:RAF1_protein
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
|
|
gptkbp:component
|
cytosol
|
|
gptkbp:discoveredBy
|
gptkb:Hartmut_Beug
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5894
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
signal transduction
serine/threonine-protein kinase activity
protein kinase activity
|
|
gptkbp:GOProcess
|
MAPK cascade
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRAF protein
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:AKT1
gptkb:BRAF_protein
gptkb:MEK1
gptkb:MEK2
gptkb:PP5
gptkb:RAS_protein
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
apoptosis regulation
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
gptkb:MAPK/ERK_pathway
|
|
gptkbp:molecularWeight
|
approximately 74 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
gptkb:6NYB
|
|
gptkbp:phosphorylates
|
Ser259
Ser338
Ser621
Tyr341
|
|
gptkbp:RefSeq
|
NP_002869.2
|
|
gptkbp:regulates
|
phosphorylation
protein-protein interaction
dephosphorylation
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
mitochondrion
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:Ser338_(CRAF)
|
|
gptkbp:bfsLayer
|
6
|