|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
Serine 530
|
|
gptkbp:alternativeName
|
gptkb:PGHS-1
gptkb:PTGS1
prostaglandin-endoperoxide synthase 1
|
|
gptkbp:associatedWith
|
fever
pain
inflammation
thromboxane synthesis
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:constitutivelyExpressed
|
true
|
|
gptkbp:discoveredIn
|
1971
|
|
gptkbp:EC_number
|
1.14.99.1
|
|
gptkbp:encodedBy
|
PTGS1 gene
|
|
gptkbp:expressedIn
|
most tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Cyclooxygenase-1
|
|
gptkbp:function
|
prostaglandin biosynthesis
catalyzes conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:gene
|
gptkb:PTGS1
|
|
gptkbp:hasIsoform
|
gptkb:COX-2
|
|
gptkbp:hasPolymorphism
|
rs3842787
rs5788
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
COX-1
|
|
gptkbp:inhibitedBy
|
gptkb:ibuprofen
gptkb:naproxen
gptkb:NSAIDs
gptkb:aspirin
|
|
gptkbp:locatedOnChromosome
|
9q32-q33.3
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
nuclear envelope
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:notInducibleBy
|
cytokines
|
|
gptkbp:notTargetOf
|
COX-2 selective inhibitors
|
|
gptkbp:OMIM
|
176805
|
|
gptkbp:orthologInMouse
|
Ptgs1
|
|
gptkbp:PDB
|
1Q4G
|
|
gptkbp:product
|
prostaglandin H2
|
|
gptkbp:role
|
platelet aggregation
renal blood flow regulation
maintenance of gastric mucosa
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
|
|
gptkbp:target
|
nonselective NSAIDs
|
|
gptkbp:UniProtID
|
P23219
|
|
gptkbp:bfsParent
|
gptkb:COX
gptkb:PTGS1
gptkb:CHEMBL29
|
|
gptkbp:bfsLayer
|
7
|