|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
Serine 530
|
|
gptkbp:alsoKnownAs
|
gptkb:COX-1
prostaglandin-endoperoxide synthase 1
|
|
gptkbp:catalyzes
|
conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:discoveredBy
|
gptkb:John_R._Vane
|
|
gptkbp:discoveredIn
|
1971
|
|
gptkbp:EC_number
|
1.14.99.1
|
|
gptkbp:encodedBy
|
PTGS1 gene
|
|
gptkbp:Entrez_Gene_ID
|
5742
|
|
gptkbp:expressedConstitutively
|
true
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
liver
stomach
platelets
intestine
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
prostaglandin biosynthesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cyclooxygenase-1
|
|
gptkbp:inhibitedBy
|
gptkb:ibuprofen
gptkb:aspirin
nonsteroidal anti-inflammatory drugs
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q32-q33.3_(human)
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
nuclear envelope
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:OMIM
|
176805
|
|
gptkbp:orthologIn
|
gptkb:dog
gptkb:horse_race
gptkb:lion
gptkb:livestock
gptkb:meat
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
1CQE
1DIY
1PTH
3N8Y
|
|
gptkbp:product
|
prostaglandin H2
|
|
gptkbp:RefSeq
|
NP_000954.1
|
|
gptkbp:role
|
platelet aggregation
gastric mucosa protection
renal blood flow regulation
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
|
|
gptkbp:UniProtID
|
P23219
|
|
gptkbp:bfsParent
|
gptkb:COX1
|
|
gptkbp:bfsLayer
|
7
|