Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:COX-1
|
| gptkbp:biologicalProcess |
prostaglandin biosynthesis
peroxidase activity cyclooxygenase activity |
| gptkbp:discoveredBy |
gptkb:John_R._Vane
|
| gptkbp:discoveredIn |
1971
|
| gptkbp:EC_number |
1.14.99.1
|
| gptkbp:expressedIn |
many tissues
|
| gptkbp:fullName |
gptkb:Prostaglandin-endoperoxide_synthase_1
|
| gptkbp:function |
catalyzes the conversion of arachidonic acid to prostaglandin H2
|
| gptkbp:gene |
gptkb:PTGS1
|
| https://www.w3.org/2000/01/rdf-schema#label |
PGHS-1
|
| gptkbp:inhibitedBy |
gptkb:ibuprofen
gptkb:aspirin nonsteroidal anti-inflammatory drugs |
| gptkbp:locatedOnChromosome |
chromosome 9q33.2
|
| gptkbp:location |
gptkb:endoplasmic_reticulum
nuclear envelope |
| gptkbp:OMIM |
176805
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:relatedTo |
gptkb:COX-2
PGHS-2 |
| gptkbp:role |
renal function
platelet aggregation regulation of gastric mucosa housekeeping enzyme |
| gptkbp:UniProtID |
P23219
|
| gptkbp:bfsParent |
gptkb:COX1
|
| gptkbp:bfsLayer |
7
|