Prostaglandin-endoperoxide synthase 1

URI: https://gptkb.org/entity/Prostaglandin-endoperoxide_synthase_1
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:COX-1
gptkb:PTGS1
gptkbp:biologicalProcess inflammatory response
peroxidase activity
prostaglandin biosynthetic process
prostaglandin-endoperoxide synthase activity
gptkbp:discoveredIn 1976
gptkbp:encodedBy PTGS1 gene
gptkbp:Entrez_Gene_ID 5742
gptkbp:enzymeCommissionNumber gptkb:EC_1.14.99.1
gptkbp:expressedIn gptkb:kidney
stomach
platelets
vascular endothelium
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function catalyzes conversion of arachidonic acid to prostaglandin H2
https://www.w3.org/2000/01/rdf-schema#label Prostaglandin-endoperoxide synthase 1
gptkbp:inhibitedBy gptkb:ibuprofen
gptkb:aspirin
nonsteroidal anti-inflammatory drugs
gptkbp:locatedOnChromosome 9q32
gptkbp:location gptkb:endoplasmic_reticulum
nuclear envelope
gptkbp:OMIM 176805
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:relatedTo gptkb:Prostaglandin-endoperoxide_synthase_2
gptkbp:structure homodimer
gptkbp:UniProtID P23219
gptkbp:bfsParent gptkb:COX1
gptkbp:bfsLayer 7