|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:COX-1
cyclooxygenase-1
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
peptic ulcer
thrombosis
|
|
gptkbp:biologicalProcess
|
regulation of blood pressure
heme binding
peroxidase activity
prostaglandin-endoperoxide synthase activity
response to wounding
|
|
gptkbp:cellularComponent
|
endoplasmic reticulum membrane
nuclear outer membrane
|
|
gptkbp:discoveredBy
|
Smith WL
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodes
|
prostaglandin G/H synthase 1
|
|
gptkbp:Entrez_Gene_ID
|
5742
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.99.1
|
|
gptkbp:expressedIn
|
gptkb:kidney
stomach
platelets
intestine
endothelium
|
|
gptkbp:fullName
|
prostaglandin-endoperoxide synthase 1
|
|
gptkbp:function
|
catalyzes conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:hasTranscriptVariant
|
NM_000962.3
|
|
gptkbp:HGNC_ID
|
9604
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTGS1
|
|
gptkbp:inhibitedBy
|
gptkb:NSAIDs
gptkb:aspirin
|
|
gptkbp:involvedIn
|
inflammatory response
platelet aggregation
prostaglandin biosynthetic process
|
|
gptkbp:locatedOnChromosome
|
9q32
|
|
gptkbp:mutationAssociatedWith
|
bleeding disorders
|
|
gptkbp:OMIM
|
176805
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInC.elegans
|
C44H4.4
|
|
gptkbp:orthologInFruitFly
|
Pxt
|
|
gptkbp:orthologInMouse
|
Ptgs1
|
|
gptkbp:orthologInZebrafish
|
ptgs1
|
|
gptkbp:pathway
|
arachidonic acid metabolism
eicosanoid synthesis
|
|
gptkbp:product
|
NP_000953.2
|
|
gptkbp:UniProtID
|
P23219
|
|
gptkbp:bfsParent
|
gptkb:DB00169
gptkb:CHEMBL960
|
|
gptkbp:bfsLayer
|
6
|