|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activation_loop
|
T-loop
|
|
gptkbp:alternativeName
|
CDKs
|
|
gptkbp:cofactor
|
gptkb:ATP
|
|
gptkbp:database
|
gptkb:UniProt
gptkb:Reactome
gptkb:KEGG
|
|
gptkbp:discoveredBy
|
gptkb:David_Morgan
gptkb:Paul_Nurse
|
|
gptkbp:enzymeClassification
|
serine/threonine kinases
|
|
gptkbp:fullName
|
Cyclin-dependent kinases
|
|
gptkbp:function
|
regulation of cell cycle
phosphorylation of target proteins
|
|
gptkbp:GO_term
|
GO:0004693
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK kinases
|
|
gptkbp:inhibitedBy
|
gptkb:CDK_inhibitors_(CKIs)
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
gptkb:CDK5
|
|
gptkbp:orthologIn
|
gptkb:Cdc2
yeast Cdc28
|
|
gptkbp:pathway
|
DNA damage response
cell cycle pathway
|
|
gptkbp:pharmaceutical_target
|
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
|
|
gptkbp:regulates
|
activated by cyclin binding
inhibited by phosphorylation
activated by dephosphorylation
|
|
gptkbp:requires
|
binding to cyclins
|
|
gptkbp:researchArea
|
cell biology
neuroscience
oncology
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
bilobal kinase domain
|
|
gptkbp:substrate
|
gptkb:p27
gptkb:p53
retinoblastoma protein (pRB)
|
|
gptkbp:bfsParent
|
gptkb:Myc
|
|
gptkbp:bfsLayer
|
6
|