Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cell cycle regulator |
| gptkbp:bind |
CDK-cyclin complexes
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
|
| gptkbp:expressedIn |
eukaryotic cells
|
| gptkbp:function |
tumor suppressor
|
| gptkbp:geneLocatedOn |
various chromosomes
|
| https://www.w3.org/2000/01/rdf-schema#label |
CDK inhibitors (CKIs)
|
| gptkbp:include |
gptkb:INK4_family
Cip/Kip family |
| gptkbp:inhibitedBy |
cell cycle progression
|
| gptkbp:member |
gptkb:p15INK4b
gptkb:p16INK4a gptkb:p18INK4c gptkb:p19INK4d gptkb:p21Cip1 gptkb:p27Kip1 gptkb:p57Kip2 |
| gptkbp:mutationAssociatedWith |
uncontrolled cell proliferation
|
| gptkbp:regulates |
gptkb:p53
TGF-beta signaling mitogenic signals cyclin-dependent kinases (CDKs) |
| gptkbp:role |
cellular senescence
DNA damage response tumor suppression cell cycle arrest |
| gptkbp:target |
anticancer drugs
|
| gptkbp:usedAs |
biomarkers in cancer research
|
| gptkbp:bfsParent |
gptkb:Cyclin_D
gptkb:CDK_kinases gptkb:cyclin-dependent_kinases |
| gptkbp:bfsLayer |
7
|