|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CDK1
|
|
gptkbp:discoveredIn
|
gptkb:Schizosaccharomyces_pombe
|
|
gptkbp:EC_number
|
2.7.11.22
|
|
gptkbp:encodedBy
|
gptkb:CDK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
983
|
|
gptkbp:enzymeClassification
|
serine/threonine-protein kinase
|
|
gptkbp:expressedIn
|
all dividing cells
|
|
gptkbp:formsComplexWith
|
gptkb:cyclin_A
gptkb:cyclin_B
|
|
gptkbp:function
|
cell cycle regulation
mitosis regulation
|
|
gptkbp:gene
|
gptkb:CDK1
|
|
gptkbp:HGNC_ID
|
1722
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cdc2
|
|
gptkbp:inhibitedBy
|
gptkb:p21
gptkb:p27
|
|
gptkbp:interactsWith
|
gptkb:cyclin_A
gptkb:cyclin_B
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q21.2
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
cell cycle arrest
embryonic lethality
|
|
gptkbp:OMIM
|
116940
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila melanogaster cdc2
Mus musculus Cdk1
Saccharomyces cerevisiae CDC28
|
|
gptkbp:PDB
|
gptkb:4Y72
5HQ0
|
|
gptkbp:phosphorylates
|
gptkb:histone_H1
Tyr15
lamin proteins
Thr14
Thr161
nuclear pore proteins
|
|
gptkbp:RefSeq
|
NP_001777.1
|
|
gptkbp:regulates
|
Wee1 kinase
Cdc25 phosphatase
|
|
gptkbp:requires
|
cell division
G2/M transition
|
|
gptkbp:role
|
gptkb:cancer
apoptosis
cell proliferation
|
|
gptkbp:structure
|
monomer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P06493
|
|
gptkbp:bfsParent
|
gptkb:CDK_kinases
gptkb:cyclin-dependent_kinases
|
|
gptkbp:bfsLayer
|
7
|