Statements (38)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:affiliatedWith |
death domain superfamily
|
| gptkbp:example |
gptkb:Apaf-1
gptkb:caspase-1 gptkb:ASC gptkb:NOD2 gptkb:RIG-I gptkb:MAVS NLRP3 Bcl-10 RAIDD |
| gptkbp:firstDescribed |
1997
|
| gptkbp:foundIn |
gptkb:NOD-like_receptors
gptkb:caspases adaptor proteins RIG-I-like receptors apoptosis-related proteins innate immune signaling proteins |
| gptkbp:fullName |
Caspase Activation and Recruitment Domain
|
| gptkbp:function |
mediates protein-protein interactions
involved in inflammation involved in apoptosis |
| gptkbp:GO_term |
GO:0035872
|
| https://www.w3.org/2000/01/rdf-schema#label |
CARD domain
|
| gptkbp:interactsWith |
DED (Death Effector Domain)
DD (Death Domain) PYD (Pyrin Domain) other CARD domains |
| gptkbp:InterPro |
IPR001315
|
| gptkbp:length |
~90
|
| gptkbp:proteinFamily |
PF00619
PS50117 |
| gptkbp:relatedTo |
innate immunity
inflammatory response cell death |
| gptkbp:structure |
composed of 6-7 alpha helices
|
| gptkbp:bfsParent |
gptkb:MDA5_protein
|
| gptkbp:bfsLayer |
7
|