Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
cysteine
|
| gptkbp:catalyzes |
hydrolysis of peptide bonds
|
| gptkbp:discoveredBy |
Willstätter and Bamann
|
| gptkbp:enzymeCommissionNumber |
EC 3.4.22.-
|
| gptkbp:example |
gptkb:calpain
caspase papain bromelain cathepsin B |
| gptkbp:family |
gptkb:caspase_family
calpain family cathepsin family papain-like proteases |
| gptkbp:firstDescribed |
1929
|
| gptkbp:foundIn |
gptkb:Bacteria
animals plants viruses |
| gptkbp:GO_term |
GO:0004197
GO:0008234 |
| https://www.w3.org/2000/01/rdf-schema#label |
cysteine protease
|
| gptkbp:inhibitedBy |
alkylating agents
E-64 cystatin iodoacetamide leupeptin |
| gptkbp:mechanismOfAction |
nucleophilic attack by cysteine thiol
|
| gptkbp:optimum_pH |
neutral to slightly acidic
|
| gptkbp:PDB |
1FCP
1ICF 1PPN |
| gptkbp:relatedTo |
gptkb:serine_protease
gptkb:aspartic_protease metalloprotease |
| gptkbp:role |
apoptosis
protein degradation antigen processing pathogenesis of diseases |
| gptkbp:significance |
involved in inflammation
involved in cancer involved in neurodegenerative diseases involved in parasitic infections |
| gptkbp:structure |
contains catalytic dyad or triad
|
| gptkbp:substrate |
varies by family
|
| gptkbp:usedIn |
gptkb:biotechnology
therapeutics meat tenderization |
| gptkbp:bfsParent |
gptkb:protease
|
| gptkbp:bfsLayer |
6
|