|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
proteolytic cleavage
|
|
gptkbp:alternativeName
|
gptkb:FLICE
gptkb:MACH
gptkb:Mch5
CASP-8
|
|
gptkbp:biologicalProcess
|
immune response
apoptotic process
cysteine-type endopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:death-inducing_signaling_complex
cytosol
|
|
gptkbp:cleavage
|
gptkb:BID
procaspase-3
procaspase-7
procaspase-6
|
|
gptkbp:domain
|
gptkb:caspase_domain
DED (Death Effector Domain)
|
|
gptkbp:Entrez_Gene_ID
|
12370
ENSMUSP00000030716
|
|
gptkbp:enzymeCommissionNumber
|
3.4.22.61
|
|
gptkbp:expressedIn
|
gptkb:thymus
liver
lymph nodes
spleen
|
|
gptkbp:fullName
|
gptkb:Caspase-8
|
|
gptkbp:function
|
initiator caspase in apoptosis
|
|
gptkbp:gene
|
Casp8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse Casp8
|
|
gptkbp:inhibitedBy
|
gptkb:c-FLIP
z-IETD-fmk
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:BID
gptkb:TRADD
gptkb:RIPK1
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
|
|
gptkbp:mutationAssociatedWith
|
embryonic lethality
impaired apoptosis
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
human CASP8
|
|
gptkbp:pathway
|
gptkb:Fas_signaling_pathway
gptkb:TNF_signaling_pathway
extrinsic apoptotic signaling pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
cleavage
|
|
gptkbp:proteinFamily
|
gptkb:caspase_family
|
|
gptkbp:RefSeq
|
NP_034088.2
|
|
gptkbp:requires
|
embryonic development
lymphocyte homeostasis
|
|
gptkbp:sequence
|
479 amino acids
|
|
gptkbp:subunit
|
heterotetramer (two large and two small subunits)
|
|
gptkbp:UniProtID
|
Q9JHX4
|
|
gptkbp:bfsParent
|
gptkb:CASP8
|
|
gptkbp:bfsLayer
|
8
|