|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:serine/threonine-protein_kinase_B-raf
gptkb:BRAF
gptkb:proto-oncogene_B-Raf
|
|
gptkbp:associatedWith
|
gptkb:LEOPARD_syndrome
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:discoveredBy
|
D. Barbacid
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:BRAF_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000157764
gptkb:BRAF
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
gptkbp:gene
|
gptkb:BRAF
|
|
gptkbp:HGNC_ID
|
1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B-Raf
|
|
gptkbp:inhibitedBy
|
gptkb:trametinib
gptkb:sorafenib
gptkb:regorafenib
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedIn
|
human chromosome 7
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
melanoma
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:1UWH
|
|
gptkbp:phosphorylates
|
gptkb:MEK
Ser446
Ser602
Thr599
Ser729
|
|
gptkbp:RefSeq
|
NM_004333
|
|
gptkbp:regulates
|
cell differentiation
cell survival
cell growth
|
|
gptkbp:structure
|
kinase domain
regulatory domain
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:Braf
|
|
gptkbp:bfsLayer
|
6
|