v-raf murine sarcoma viral oncogene homolog B1

URI: https://gptkb.org/entity/v-raf_murine_sarcoma_viral_oncogene_homolog_B1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:BRAF
gptkbp:associatedWith gptkb:cancer
colorectal cancer
melanoma
gptkbp:discoveredBy Davies et al.
gptkbp:discoveredIn 2002
gptkbp:encodes gptkb:B-Raf_proto-oncogene_serine/threonine-protein_kinase
gptkbp:Entrez_Gene_ID gptkb:ENSG00000157764
673
gptkbp:expressedIn various tissues
gptkbp:function signal transduction
MAPK/ERK pathway activation
gptkbp:geneType protein-coding
gptkbp:HGNC_ID gptkb:HGNC:1097
https://www.w3.org/2000/01/rdf-schema#label v-raf murine sarcoma viral oncogene homolog B1
gptkbp:length 766 amino acids
gptkbp:locatedOnChromosome gptkb:7q34
gptkbp:mutationAssociatedWith V600E
gptkbp:OMIM 164757
gptkbp:orthologIn gptkb:BRAF
gptkbp:orthologInMouse gptkb:Braf
gptkbp:proteinFamily gptkb:RAF_kinase_family
gptkbp:regulates cell differentiation
cell survival
cell growth
gptkbp:targetOfDrug gptkb:trametinib
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
gptkbp:UniProtID gptkb:P15056
gptkbp:bfsParent gptkb:BRAF
gptkbp:bfsLayer 5