|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Binding_immunoglobulin_protein
gptkb:GRP78
|
|
gptkbp:amendedBy
|
protein conformation
|
|
gptkbp:binds
|
misfolded proteins
unfolded proteins
|
|
gptkbp:conservedIn
|
eukaryotes
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:downregulatedIn
|
cellular homeostasis
|
|
gptkbp:encodedBy
|
gptkb:HSPA5
|
|
gptkbp:expressedIn
|
all eukaryotic cells
|
|
gptkbp:family
|
gptkb:heat_shock_protein_70_family
|
|
gptkbp:function
|
protein folding
unfolded protein response
molecular chaperone
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BiP
|
|
gptkbp:inhibitedBy
|
activation of UPR sensors in unstressed cells
apoptosis under ER stress
|
|
gptkbp:interactsWith
|
gptkb:ATF6
gptkb:IRE1
gptkb:PERK
|
|
gptkbp:involvedIn
|
gptkb:ER-associated_degradation_(ERAD)
antigen processing
immunoglobulin assembly
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q33.3
|
|
gptkbp:marking
|
ER stress
|
|
gptkbp:molecularWeight
|
78 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_melanogaster_(Hsc70-3)
gptkb:Saccharomyces_cerevisiae_(Kar2p)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
protein quality control
ER stress response
UPR signaling
|
|
gptkbp:releasedFromPrison
|
UPR sensors upon ER stress
|
|
gptkbp:requires
|
cell survival under stress
|
|
gptkbp:sequence
|
gptkb:UniProt:P11021
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:structure
|
C-terminal substrate-binding domain
N-terminal ATPase domain
|
|
gptkbp:target
|
drug development
|
|
gptkbp:upregulatedBy
|
heat shock
ER stress
|
|
gptkbp:usedIn
|
biomedical research
|
|
gptkbp:bfsParent
|
gptkb:Turkcell
gptkb:Binding_immunoglobulin_protein
gptkb:GRP78
gptkb:HSPA5
gptkb:Hspa5
gptkb:yeast_Kar2p
|
|
gptkbp:bfsLayer
|
7
|