|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:BiP
gptkb:GRP78
|
|
gptkbp:component
|
endoplasmic reticulum lumen
|
|
gptkbp:discoveredBy
|
Joseph Sambrook
Mary-Jane Gething
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:encodedBy
|
HSPA5 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000141424
|
|
gptkbp:expressedIn
|
ubiquitous
high in secretory tissues
|
|
gptkbp:family
|
gptkb:heat_shock_protein_70_family
|
|
gptkbp:function
|
protein folding
unfolded protein response
ATP binding
protein binding
molecular chaperone
|
|
gptkbp:gene
|
gptkb:HSPA5
|
|
gptkbp:GOProcess
|
response to unfolded protein
|
|
gptkbp:HGNC_ID
|
5238
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSPA5
|
|
gptkbp:interactsWith
|
gptkb:ATF6
DNAJC10
EIF2AK3
PDIA6
|
|
gptkbp:length
|
654 amino acids
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
9q33.3
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:OMIM
|
138120
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Hspa5
rat Hspa5
|
|
gptkbp:pathway
|
unfolded protein response
protein processing in endoplasmic reticulum
|
|
gptkbp:PDB
|
gptkb:3LDL
gptkb:5E84
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NP_005338
|
|
gptkbp:regulates
|
upregulated by ER stress
|
|
gptkbp:significance
|
implicated in cancer
implicated in neurodegenerative diseases
biomarker for ER stress
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
cell surface (under stress)
|
|
gptkbp:UniProtID
|
P11021
|
|
gptkbp:bfsParent
|
gptkb:Bip_(gene)
gptkb:Bip_(protein)
|
|
gptkbp:bfsLayer
|
6
|